Ontology highlight
ABSTRACT:
SUBMITTER: Milligan C
PROVIDER: S-EPMC4392343 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Milligan Caitlin C Richardson Barbra A BA John-Stewart Grace G Nduati Ruth R Overbaugh Julie J
Cell host & microbe 20150401 4
In addition to direct effects on virus infectivity, antibodies mediate antibody-dependent cellular cytotoxicity (ADCC), the killing of an antibody-coated virus-infected cell by cytotoxic effector cells. Although ADCC has been suggested to protect against HIV, the relationship between HIV-specific ADCC antibodies at the time of HIV exposure and infection outcome in humans remains to be assessed. We evaluated the ADCC activity of passively acquired antibodies in infants born to HIV-infected mother ...[more]