Ontology highlight
ABSTRACT:
SUBMITTER: Urosa A
PROVIDER: S-EPMC4413218 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Urosa Aitor A Marcos Isidro S IS Díez David D Lithgow Anna A Plata Gabriela B GB Padrón José M JM Padrón José M JM Basabe Pilar P
Marine drugs 20150420 4
The first synthesis of Luffarin I, sesterterpenolide isolated from sponge Luffariella geometrica, has been accomplished from commercially available sclareol. The key strategy involved in this synthesis is the diastereoselective reduction of an intermediate ketone. Luffarin I against human solid tumor cell lines showed antiproliferative activities (GI50) in the range 12-17 μM. ...[more]