Ontology highlight
ABSTRACT:
SUBMITTER: Jacinto MP
PROVIDER: S-EPMC4497583 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Jacinto M P V MP Flores M S MS Lin Z Z Concepcion G P GP Schmidt E W EW Faulkner S S Villaraza A J L AJ
RSC advances 20140101 71
An alternative and facile solution/solid-phase approach is reported for the total synthesis of neuroactive peptide, nobilamide B. <i>Z</i>-Dhb was formed in solution via EDC/CuCl induced elimination. The solid-phase synthesis employed HBTU/Oxyma Pure™ coupling using Barlos resin. Synthetic nobilamide B was also found to be neuroactive in primary cultures of dorsal root ganglion (DRG) neurons. ...[more]