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Synthesis and bioactivity of nobilamide B.


ABSTRACT: An alternative and facile solution/solid-phase approach is reported for the total synthesis of neuroactive peptide, nobilamide B. Z-Dhb was formed in solution via EDC/CuCl induced elimination. The solid-phase synthesis employed HBTU/Oxyma Pure™ coupling using Barlos resin. Synthetic nobilamide B was also found to be neuroactive in primary cultures of dorsal root ganglion (DRG) neurons.

SUBMITTER: Jacinto MP 

PROVIDER: S-EPMC4497583 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Synthesis and bioactivity of nobilamide B.

Jacinto M P V MP   Flores M S MS   Lin Z Z   Concepcion G P GP   Schmidt E W EW   Faulkner S S   Villaraza A J L AJ  

RSC advances 20140101 71


An alternative and facile solution/solid-phase approach is reported for the total synthesis of neuroactive peptide, nobilamide B. <i>Z</i>-Dhb was formed in solution via EDC/CuCl induced elimination. The solid-phase synthesis employed HBTU/Oxyma Pure™ coupling using Barlos resin. Synthetic nobilamide B was also found to be neuroactive in primary cultures of dorsal root ganglion (DRG) neurons. ...[more]

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