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Stereochemical evaluation of bis(phosphine) copper catalysts for the asymmetric alkylation of 3-bromooxindoles with ?-arylated malonate esters.

ABSTRACT: An improved method for the asymetric alkylation of 3-bromooxindoles with ?-arylated malonate esters is described. The asymmetric alkylation demonstrated was achieved up to 70% ee utilizing a copper(II) bis(phosphine) complex.

SUBMITTER: Lee CW

PROVIDER: S-EPMC4429905 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Stereochemical evaluation of bis(phosphine) copper catalysts for the asymmetric alkylation of 3-bromooxindoles with α-arylated malonate esters.

Lee Chung Whan CW Han Seo-Jung SJ Virgil Scott C SC Stoltz Brian M BM

Tetrahedron 20150601 22

An improved method for the asymetric alkylation of 3-bromooxindoles with α-arylated malonate esters is described. The asymmetric alkylation demonstrated was achieved up to 70% ee utilizing a copper(II) bis(phosphine) complex. ...[more]

PMID: 25983348

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