Ontology highlight
ABSTRACT:
SUBMITTER: Yokoyama T
PROVIDER: S-EPMC4550876 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Yokoyama Takeshi T Ueda Mitsuharu M Ando Yukio Y Mizuguchi Mineyuki M
Scientific reports 20150827
Transthyretin (TTR) is a homotetrameric protein involved in human hereditary amyloidoses. The discovery and development of small molecules that inhibit the amyloid fibril formation of TTR is one of the therapeutic strategies for these diseases. Herein, we discovered that γ-mangostin (γ-M) is an effective inhibitor against the amyloid fibril formation of V30M amyloidogenic TTR. In-vitro binding assays revealed that γ-M was the most potent of the selected xanthone derivatives, and it bound to the ...[more]