Klotho-related Molecules Upregulated by Smoking Habit in Apparently Healthy Men: A Cross-sectional Study.

ABSTRACT: While aging is unavoidable, the aging mechanism is still unclear because of its complexity. Smoking causes premature death and is considered as an environmental aging accelerator. In the present study, we focused on the influence of smoking to the serum concentration of anti-aging protein ?-klotho (?Kl) and the ?-klotho-associated protein fibroblast growth factor (FGF)-21 in men. Subjects consisted of apparently healthy men over 40 years of age who underwent health examination. Physical and biochemical parameters, including the levels of several cytokines and growth factors, were obtained from the subjects. Among middle-aged men (46.1 ± 5.1 years), serum levels of FGF-21, soluble ?Kl (s?Kl), and inflammation-related cytokine interleukin (IL)-6 were significantly higher in smokers than in never-smokers. Serum levels of FGF-21 increased and correlated with alanine transaminase, ? guanosine-5'-triphosphate, and total cholesterol only in smokers, suggesting FGF-21 as a metabolic disorder-related factor in smokers. In aged men (60.3 ± 1.7 years), although the serum levels of s?Kl in never-smokers were low, smokers showed highly increased serum levels of s?Kl. Serum levels of s?Kl was correlated with IL-6 in middle-aged never-smokers, suggesting s?Kl regulates IL-6. However, this correlation was disrupted in smokers and aged men.

SUBMITTER: Nakanishi K 

PROVIDER: S-EPMC4585559 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature