Ontology highlight
ABSTRACT:
SUBMITTER: Tello-Aburto R
PROVIDER: S-EPMC4629797 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Organic & biomolecular chemistry 20150924 40
The absolute stereochemistry of the cystargolides was determined by total synthesis. Evaluation of synthetic cystargolides and derivatives showed that the natural (2S,3R) stereochemistry is essential for activity. Moreover, benzyl esters (-)-10 and (-)-15 were found to be about 100 times more potent, and to selectively kill MCF-7 cancerous cells. ...[more]