Ontology highlight
ABSTRACT:
SUBMITTER: Smith E
PROVIDER: S-EPMC4659430 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Smith Emery E Chase Peter P Niswender Colleen M CM Utley Thomas J TJ Sheffler Douglas J DJ Noetzel Meredith J MJ Lamsal Atin A Wood Michael R MR Conn P Jeffrey PJ Lindsley Craig W CW Madoux Franck F Acosta Mary M Scampavia Louis L Spicer Timothy T Hodder Peter P
Journal of biomolecular screening 20150415 7
Muscarinic acetylcholine receptors (mAChRs) have long been viewed as viable targets for novel therapeutic agents for the treatment of Alzheimer's disease and other disorders involving impaired cognitive function. In an attempt to identify orthosteric and allosteric modulators of the muscarinic acetylcholine receptor M(4) (M(4)), we developed a homogenous, multiparametric, 1536-well assay to measure M(4) receptor agonism, positive allosteric modulation (PAM), and antagonism in a single well. This ...[more]