Disruption and eradication of P. aeruginosa biofilms using nitric oxide-releasing chitosan oligosaccharides.
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ABSTRACT:
SUBMITTER: Reighard KP
PROVIDER: S-EPMC4695972 | biostudies-literature | 2015 Oct-Nov
REPOSITORIES: biostudies-literature
Publications
Disruption and eradication of P. aeruginosa biofilms using nitric oxide-releasing chitosan oligosaccharides.
Reighard Katelyn P KP Hill David B DB Dixon Graham A GA Worley Brittany V BV Schoenfisch Mark H MH
Biofouling 20151001 9-10
Biofilm disruption and eradication were investigated as a function of nitric oxide- (NO) releasing chitosan oligosaccharide dose and the results compared with control (i.e., non-NO-releasing) chitosan oligosaccharides and tobramycin. Quantification of biofilm expansion/contraction and multiple-particle tracking microrheology were used to assess the structural integrity of the biofilm before and after antibacterial treatment. While tobramycin had no effect on the physical properties of the biofil ...[more]
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