Role of Nitric Oxide-Releasing Chitosan Oligosaccharides on Mucus Viscoelasticity.
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ABSTRACT:
SUBMITTER: Reighard KP
PROVIDER: S-EPMC6178828 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
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Role of Nitric Oxide-Releasing Chitosan Oligosaccharides on Mucus Viscoelasticity.
Reighard Katelyn P KP Ehre Camille C Rushton Zachary L ZL Ahonen Mona Jasmine R MJR Hill David B DB Schoenfisch Mark H MH
ACS biomaterials science & engineering 20170515 6
Nitric oxide (NO)-releasing chitosan oligosaccharides were modified with ester functional groups to examine how the mucoadhesive nature of the scaffold impacts the ability of NO to degrade mucins from human bronchial epithelial cell cultures and clinical sputum samples collected from patients with cystic fibrosis (CF). Agarose gel electrophoresis experiments indicated that the mucoadhesive NO-releasing chitosan oligosaccharides degraded both the purified mucins and sputum, while control scaffold ...[more]
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