Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC4732909 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Liu Zheng Z Liu Yang Y Chang Yuan Y Seyf Hamid Reza HR Henry Asegun A Mattheyses Alexa L AL Yehl Kevin K Zhang Yun Y Huang Zhuangqun Z Salaita Khalid K
Nature methods 20151214 2
To control receptor tension optically at the cell surface, we developed an approach involving optomechanical actuator nanoparticles that are controlled with near-infrared light. Illumination leads to particle collapse, delivering piconewton forces to specific cell surface receptors with high spatial and temporal resolution. We demonstrate optomechanical actuation by controlling integrin-based focal adhesion formation, cell protrusion and migration, and T cell receptor activation. ...[more]