Dataset Information

Data taken from the review article "Radiation and circulatory disease" and used in the associated meta-analysis.

ABSTRACT: This WinZip archive 'Combined R, EpiWin & datafiles (rev 2016-9-29).zip' contains the basic data used in the meta-analysis of doi 10.1016/j.mrrev.2016.07.008 (M.P. Little, 2016) [1], complete with R (R Project version 3.2.2, 2015) [2] code used for meta-regression etc. The basic data is derived from the papers of Mulrooney et al. (D.A. Mulrooney, M.W. Yeazel, T. Kawashima, A.C. Mertens, P. Mitby, M. Stovall, S.S. Donaldson, D.M. Green, C.A. Sklar, L.L. Robison, W.M. Leisenring, 2009) [3], Cutter et al. (D.J. Cutter, M. Schaapveld, S.C. Darby, M. Hauptmann, F.A. van Nimwegen, A.D.G. Krol, C.P.M. Janus, F.E. van Leeuwen, B.M.P. Aleman, 2015) [4] and van Nimwegen et al. (F.A. van Nimwegen, M. Schaapveld, D.J. Cutter, C.P.M. Janus, A.D.G. krol, M. Hauptmann, K. Kooijman, J. Roesink, R. van der Maazen, S.C. Darby, B.M.P. Aleman, F.E. van Leeuwen, 2016) [5], and other data taken from various Tables in the papers summarized in Tables 2-4 of doi 10.1016/j.mrrev.2016.07.008 [1]. The archive also contains R [2] script files that perform the meta-analysis.

SUBMITTER: Little MP

PROVIDER: S-EPMC5123126 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Publications

Data taken from the review article "Radiation and circulatory disease" and used in the associated meta-analysis.

Little Mark P MP

Data in brief 20161109

This WinZip archive 'Combined R, EpiWin & datafiles (rev 2016-9-29).zip' contains the basic data used in the meta-analysis of doi 10.1016/j.mrrev.2016.07.008 (M.P. Little, 2016) [1], complete with R (R Project version 3.2.2, 2015) [2] code used for meta-regression etc. The basic data is derived from the papers of Mulrooney et al. (D.A. Mulrooney, M.W. Yeazel, T. Kawashima, A.C. Mertens, P. Mitby, M. Stovall, S.S. Donaldson, D.M. Green, C.A. Sklar, L.L. Robison, W.M. Leisenring, 2009) [3], Cutter ...[more]

PMID: 27900355

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Project description:BackgroundWhile recommended by international societal guidelines in the paediatric population, the use of venoarterial extracorporeal membrane oxygenation (VA ECMO) as mechanical circulatory support for refractory septic shock in adults is controversial. We aimed to characterise the outcomes of adults with septic shock requiring VA ECMO, and identify factors associated with survival.MethodsWe searched Pubmed, Embase, Scopus and Cochrane databases from inception until 1st June 2021, and included all relevant publications reporting on > 5 adult patients requiring VA ECMO for septic shock. Study quality and certainty in evidence were assessed using the appropriate Joanna Briggs Institute checklist, and the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach, respectively. The primary outcome was survival to hospital discharge, and secondary outcomes included intensive care unit length of stay, duration of ECMO support, complications while on ECMO, and sources of sepsis. Random-effects meta-analysis (DerSimonian and Laird) were conducted.Data synthesisWe included 14 observational studies with 468 patients in the meta-analysis. Pooled survival was 36.4% (95% confidence interval [CI]: 23.6%-50.1%). Survival among patients with left ventricular ejection fraction (LVEF) < 20% (62.0%, 95%-CI: 51.6%-72.0%) was significantly higher than those with LVEF > 35% (32.1%, 95%-CI: 8.69%-60.7%, p = 0.05). Survival reported in studies from Asia (19.5%, 95%-CI: 13.0%-26.8%) was notably lower than those from Europe (61.0%, 95%-CI: 48.4%-73.0%) and North America (45.5%, 95%-CI: 16.7%-75.8%). GRADE assessment indicated high certainty of evidence for pooled survival.ConclusionsWhen treated with VA ECMO, the majority of patients with septic shock and severe sepsis-induced myocardial depression survive. However, VA ECMO has poor outcomes in adults with septic shock without severe left ventricular depression. VA ECMO may be a viable treatment option in carefully selected adult patients with refractory septic shock.

Dataset Information

Data taken from the review article "Radiation and circulatory disease" and used in the associated meta-analysis.

Publications

Data taken from the review article "Radiation and circulatory disease" and used in the associated meta-analysis.

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