Ontology highlight
ABSTRACT:
SUBMITTER: Singh SK
PROVIDER: S-EPMC5159667 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Singh Sameer K SK Qiao Zhen Z Song Lihua L Jani Vijay V Rice William W Eng Edward E Coleman Robert A RA Liu Wei-Li WL
Genes & development 20161101 22
The master tumor suppressor p53 activates transcription in response to various cellular stresses in part by facilitating recruitment of the transcription machinery to DNA. Recent studies have documented a direct yet poorly characterized interaction between p53 and RNA polymerase II (Pol II). Therefore, we dissected the human p53/Pol II interaction via single-particle cryo-electron microscopy, structural docking, and biochemical analyses. This study reveals that p53 binds Pol II via the Rpb1 and ...[more]