Ontology highlight
ABSTRACT:
SUBMITTER: Luo ST
PROVIDER: S-EPMC5292721 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Luo Shun-Tao ST Zhang Dong-Mei DM Qin Qing Q Lu Lian L Luo Min M Guo Fu-Chun FC Shi Hua-Shan HS Jiang Li L Shao Bin B Li Meng M Yang Han-Shuo HS Wei Yu-Quan YQ
Scientific reports 20170206
The simultaneous increases in blood lactic acid and erythrocytes after intense exercise could suggest a link between lactate and the erythropoiesis. However, the effects of lactic acid on erythropoiesis remain to be elucidated. Here, we utilized a mouse model to determine the role of lactic acid in this process in parallel with studies using leukaemic K562 cells. Treatment of K562 cells in vitro with lactic acid increased the mRNA and protein expression of haemoglobin genes and the frequency of ...[more]