Ontology highlight
ABSTRACT:
SUBMITTER: Kim Wiese A
PROVIDER: S-EPMC5531461 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Kim Wiese Ara A Schluterman Burdine Marie M Turnage Richard H RH Tackett Alan J AJ Burdine Lyle J LJ
PloS one 20170727 7
Loss of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity in mammals results in severe combined immuno-deficiency (SCID). This SCID phenotype has been postulated to be due solely to the function of DNA-PKcs in V(D)J recombination, a process critical for lymphocyte maturation. However; we show that DNA-PKcs is required for IL-2 production via regulation of the calcineurin signaling pathway. Reducing DNA-PKcs activity in activated T cells either by shRNA or an inhibitor significan ...[more]