Ontology highlight
ABSTRACT:
SUBMITTER: Chi W
PROVIDER: S-EPMC5536896 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Chi Wei W Hua Xia X Chen Xin X Bian Fang F Yuan Xiaoyong X Zhang Lili L Wang Xiaoran X Chen Ding D Deng Ruzhi R Li Zhijie Z Liu Yizhi Y de Paiva Cintia S CS Pflugfelder Stephen C SC Li De-Quan DQ
Journal of autoimmunity 20170224
The concept of innate immunity has been expanded to recognize environmental pathogens other than microbial components. However, whether and how the innate immunity is initiated by epithelium in response to environmental physical challenges such as low humidity and high osmolarity in an autoimmune disease, dry eye, is still largely unknown. Using two experimental dry eye models, primary human corneal epithelial cultures exposed to hyperosmolarity and mouse ocular surface facing desiccating stress ...[more]