Ontology highlight
ABSTRACT:
SUBMITTER: Guan Z
PROVIDER: S-EPMC5617632 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Guan Zhuo Z Bykhovskaia Maria M Jorquera Ramon A RA Sutton Roger Bryan RB Akbergenova Yulia Y Littleton J Troy JT
eLife 20170912
The synaptic vesicle Ca<sup>2+</sup> sensor Synaptotagmin binds Ca<sup>2+</sup> through its two C2 domains to trigger membrane interactions. Beyond membrane insertion by the C2 domains, other requirements for Synaptotagmin activity are still being elucidated. To identify key residues within Synaptotagmin required for vesicle cycling, we took advantage of observations that mutations in the C2B domain Ca<sup>2+</sup>-binding pocket dominantly disrupt release from invertebrates to humans. We perfor ...[more]