Ontology highlight
ABSTRACT:
SUBMITTER: Hou XM
PROVIDER: S-EPMC5737514 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Hou Xi-Miao XM Fu Yi-Ben YB Wu Wen-Qiang WQ Wang Lei L Teng Fang-Yuan FY Xie Ping P Wang Peng-Ye PY Xi Xu-Guang XG
Nucleic acids research 20171101 19
G-quadruplex (G4) can be formed by G-rich DNA sequences that are widely distributed throughout the human genome. Although G-triplex and G-hairpin have been proposed as G4 folding intermediates, their formation still requires further investigation by experiments. Here, we employed single-molecule FRET to characterize the folding dynamics of G4 from human telomeric sequence. First, we observed four states during G4 folding initially assigned to be anti-parallel G4, G-triplex, G-hairpin and unfolde ...[more]