Ontology highlight
ABSTRACT:
SUBMITTER: Ju HP
PROVIDER: S-EPMC6044606 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
ACS omega 20160824 2
G-Quadruplex DNA structure has been proven to be a binding target for small molecular organic compounds and hence regarded as a promising pharmacological target. Cisplatin is a widely used chemotherapy drug that targets duplex DNA and was recently shown to react also with G-quadruplex, implying that cisplatin actually may also target G-quadruplex. In this work, we employed magnetic tweezers to investigate the influence of cisplatin on the folding kinetics of single human telomeric G-quadruplex. ...[more]