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Folding Kinetics of Single Human Telomeric G-Quadruplex Affected by Cisplatin.

ABSTRACT: G-Quadruplex DNA structure has been proven to be a binding target for small molecular organic compounds and hence regarded as a promising pharmacological target. Cisplatin is a widely used chemotherapy drug that targets duplex DNA and was recently shown to react also with G-quadruplex, implying that cisplatin actually may also target G-quadruplex. In this work, we employed magnetic tweezers to investigate the influence of cisplatin on the folding kinetics of single human telomeric G-quadruplex. It was revealed that cisplatin and G-quadruplex interact in two different and competitive ways that depend on cisplatin concentration.

SUBMITTER: Ju HP

PROVIDER: S-EPMC6044606 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Folding Kinetics of Single Human Telomeric G-Quadruplex Affected by Cisplatin.

Ju Hai-Peng HP Wang Yi-Zhou YZ You Jing J Hou Xi-Miao XM Xi Xu-Guang XG Dou Shuo-Xing SX Li Wei W Wang Peng-Ye PY

ACS omega 20160824 2

G-Quadruplex DNA structure has been proven to be a binding target for small molecular organic compounds and hence regarded as a promising pharmacological target. Cisplatin is a widely used chemotherapy drug that targets duplex DNA and was recently shown to react also with G-quadruplex, implying that cisplatin actually may also target G-quadruplex. In this work, we employed magnetic tweezers to investigate the influence of cisplatin on the folding kinetics of single human telomeric G-quadruplex. ...[more]

PMID: 30023477

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