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Scalable Access to Arylomycins via C-H Functionalization Logic.

ABSTRACT: Arylomycins are a promising class of "latent" antibacterial natural products currently in preclinical development. Access to analogues within this family has previously required a lengthy route involving multiple functional group manipulations that is costly and time-intensive on scale. This study presents a simplified route predicated on simple C-H functionalization logic that is enabled by a Cu-mediated oxidative phenol coupling that mimics the putative biosynthesis. This operationally simple macrocyclization is the largest of its kind and can be easily performed on gram scale. The application of this new route to a formal synthesis of the natural product and a collection of new analogues along with their biological evaluation is also reported.

SUBMITTER: Peters DS

PROVIDER: S-EPMC5817625 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Scalable Access to Arylomycins via C-H Functionalization Logic.

Peters David S DS Romesberg Floyd E FE Baran Phil S PS

Journal of the American Chemical Society 20180206 6

Arylomycins are a promising class of "latent" antibacterial natural products currently in preclinical development. Access to analogues within this family has previously required a lengthy route involving multiple functional group manipulations that is costly and time-intensive on scale. This study presents a simplified route predicated on simple C-H functionalization logic that is enabled by a Cu-mediated oxidative phenol coupling that mimics the putative biosynthesis. This operationally simple ...[more]

PMID: 29381350

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