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CuH-Catalyzed Asymmetric Hydroamidation of Vinylarenes.

ABSTRACT: A CuH-catalyzed enantioselective hydroamidation reaction of vinylarenes has been developed using readily accessible 1,4,2-dioxazol-5-ones as electrophilic amidating reagents. This method provides a straightforward and efficient approach to synthesize chiral amides in good yields with high levels of enantiopurity under mild conditions. Moreover, this transformation tolerates substrates bearing a broad range of functional groups.

SUBMITTER: Zhou Y

PROVIDER: S-EPMC5992098 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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CuH-Catalyzed Asymmetric Hydroamidation of Vinylarenes.

Zhou Yujing Y Engl Oliver D OD Bandar Jeffrey S JS Chant Emma D ED Buchwald Stephen L SL

Angewandte Chemie (International ed. in English) 20180430 22

A CuH-catalyzed enantioselective hydroamidation reaction of vinylarenes has been developed using readily accessible 1,4,2-dioxazol-5-ones as electrophilic amidating reagents. This method provides a straightforward and efficient approach to synthesize chiral amides in good yields with high levels of enantiopurity under mild conditions. Moreover, this transformation tolerates substrates bearing a broad range of functional groups. ...[more]

PMID: 29660768

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