Unknown

Dataset Information

0

Zinc (II)-Mediated Selective O-Benzylation of 2-Oxo-1,2-Dihydropyridines Systems.

ABSTRACT: The selective O-benzylation of 2-oxo-1,2-dihydropyridines plays a critical role in organic synthesis of natural products and biological active molecules. Herein we report a novel ternary system of ZnO, ZnCl? and N,N-diisopropylethylamine (DIEA), that is highly effective for selective O-benzylation of 2-oxo-1,2-dihydropyridines using abundant substituted benzyl halides and related substituted 2-oxo-1,2-dihydropyridines compounds. This process allows access to a variety of O-benzyl products under mild reaction conditions, which are important synthetic intermediates in the protection of functional groups, and represents a new method toward the development for the O-benzylation of 2-oxo-1,2-dihydropyridines.

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC6100589 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Zinc (II)-Mediated Selective <i>O</i>-Benzylation of 2-Oxo-1,2-Dihydropyridines Systems.

Zhou Qifan Q   Du Fangyu F   Liang Xinjie X   Liu Wenqiang W   Fang Ting T   Chen Guoliang G  

Molecules (Basel, Switzerland) 20180720 7

The selective <i>O</i>-benzylation of 2-oxo-1,2-dihydropyridines plays a critical role in organic synthesis of natural products and biological active molecules. Herein we report a novel ternary system of ZnO, ZnCl₂ and <i>N</i>,<i>N</i>-diisopropylethylamine (DIEA), that is highly effective for selective <i>O</i>-benzylation of 2-oxo-1,2-dihydropyridines using abundant substituted benzyl halides and related substituted 2-oxo-1,2-dihydropyridines compounds. This process allows access to a variety  ...[more]

Similar Datasets

Unknown Tetra-aqua-bis(2-oxo-1,2-dihydro-pyridine-5-sulfonato-?O)zinc(II).
| S-EPMC2971040 | biostudies-literature
Unknown Pt(II)-catalyzed synthesis of 1,2-dihydropyridines from aziridinyl propargylic esters.
| S-EPMC3384524 | biostudies-literature
Unknown Redox cycloisomerization approach to 1,2-dihydropyridines.
| S-EPMC4883060 | biostudies-literature
Unknown Hexaaqua-zinc(II) 4,4'-(1,2-dihy-droxy-ethane-1,2-di-yl)dibenzoate monohydrate.
| S-EPMC3007234 | biostudies-literature
Unknown trans-Diaqua-bis-(cyclo-hexane-1,2-diamine)-zinc(II) dichloride.
| S-EPMC3099959 | biostudies-literature
Unknown Cu(I)-Catalyzed 1,2-Alkynyl-propargylation and -benzylation of Benzyne Derivatives.
| S-EPMC8392099 | biostudies-literature
Unknown Tetra-aqua-bis(2-oxo-1,2-dihydro-quinoline-4-carboxyl-ato-κO)nickel(II).
| S-EPMC2960272 | biostudies-literature
Unknown (?-Ethane-1,2-diamine-?N:N')bis-[bis-(ethane-1,2-diamine-?N,N')zinc(II)] tetra-kis-(perchlorate).
| S-EPMC3009181 | biostudies-literature
Unknown Dibromido[N-propyl-N'-(2-pyridylmethyl-idene)ethane-1,2-diamine]zinc(II).
| S-EPMC2962000 | biostudies-literature
Unknown Diaqua-bis(4-oxo-1,4-dihydro-pyridine-3-sulfonato-?O,O)zinc(II).
| S-EPMC2971298 | biostudies-literature