Ontology highlight
ABSTRACT:
SUBMITTER: Yang Z
PROVIDER: S-EPMC6125455 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Yang Ziyi Z Pan Lijia L Liu Shilei S Li Fengnan F Lv Wenjie W Shu Yijun Y Dong Ping P
Cancer science 20180728 9
Imatinib has revolutionized the treatment of gastrointestinal stromal tumors (GIST); however, primary and secondary resistance to imatinib is still a major cause of treatment failure. Multiple mechanisms are involved in this progression. In the present study, we reported a novel mechanism for the acquired resistance to imatinib, which was induced by enhanced Ca<sup>2+</sup> influx via stromal-interacting molecule 1 (STIM1)-mediated store-operated Ca<sup>2+</sup> entry (SOCE). We found that the S ...[more]