Ontology highlight
ABSTRACT:
SUBMITTER: Nazarko O
PROVIDER: S-EPMC6137404 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
iScience 20180430
Adhesion G-protein-coupled receptors (aGPCRs) play critical roles in diverse cellular processes in neurobiology, development, immunity, and numerous diseases. The lack of molecular understanding of their activation mechanisms, especially with regard to the transmembrane domains, hampers further studies to facilitate aGPCR-targeted drug development. Latrophilin-1/ADGRL1 is a model aGPCR that regulates synapse formation and embryogenesis, and its mutations are associated with cancer and attention- ...[more]