Ontology highlight
ABSTRACT:
SUBMITTER: Dutter BF
PROVIDER: S-EPMC6151185 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Dutter Brendan F BF Ender Anna A Sulikowski Gary A GA Weaver C David CD
Organic & biomolecular chemistry 20180801 31
Thallium (Tl+) flux assays enable imaging of potassium (K+) channel activity in cells and tissues by exploiting the permeability of K+ channels to Tl+ coupled with a fluorescent Tl+ sensitive dye. Common Tl+ sensing dyes utilize fluorescein as the fluorophore though fluorescein exhibits certain undesirable properties in these assays including short excitation wavelengths and pH sensitivity. To overcome these drawbacks, the replacement of fluorescein with rhodols was investigated. A library of 13 ...[more]