Ontology highlight
ABSTRACT:
SUBMITTER: Quintino L
PROVIDER: S-EPMC6187056 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Molecular therapy. Methods & clinical development 20180904
Regulation of therapeutic transgene expression can increase the safety of gene therapy interventions, especially when targeting critical organs such as the brain. Although several gene expression systems have been described, none of the current systems has the required safety profile for clinical applications. Our group has previously adapted a system for novel gene regulation based on the destabilizing domain degron technology to successfully regulate glial cell-line derived neurotrophic factor ...[more]