Ontology highlight
ABSTRACT:
SUBMITTER: Bhat C
PROVIDER: S-EPMC6316490 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Bhat Chinmay C Ilina Polina P Tilli Irene I Voráčová Manuela M Bruun Tanja T Barba Victoria V Hribernik Nives N Lillsunde Katja-Emilia KE Mäki-Lohiluoma Eero E Rüffer Tobias T Lang Heinrich H Yli-Kauhaluoma Jari J Kiuru Paula P Tammela Päivi P
Marine drugs 20181203 12
The first total synthesis of the marine bromotyrosine purpurealidin I (<b>1</b>) using trifluoroacetoxy protection group and its dimethylated analog (<b>29</b>) is reported along with 16 simplified bromotyrosine derivatives lacking the tyramine moiety. Their cytotoxicity was evaluated against the human malignant melanoma cell line (A-375) and normal skin fibroblast cells (Hs27) together with 33 purpurealidin-inspired simplified amides, and the structure⁻activity relationships were investigated. ...[more]