Ontology highlight
ABSTRACT:
SUBMITTER: Rostol JT
PROVIDER: S-EPMC6430669 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Rostøl Jakob T JT Marraffini Luciano A LA
Nature microbiology 20190128 4
Type III-A CRISPR-Cas systems employ the Cas10-Csm complex to destroy bacteriophages and plasmids, using a guide RNA to locate complementary RNA molecules from the invader and trigger an immune response that eliminates the infecting DNA. In addition, these systems possess the non-specific RNase Csm6, which provides further protection for the host. While the role of Csm6 in immunity during phage infection has been determined, how this RNase is used against plasmids is unclear. Here, we show that ...[more]