Ontology highlight
ABSTRACT:
SUBMITTER: Jaffe AE
PROVIDER: S-EPMC6438700 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Jaffe Andrew E AE Straub Richard E RE Shin Joo Heon JH Tao Ran R Gao Yuan Y Collado-Torres Leonardo L Kam-Thong Tony T Xi Hualin S HS Quan Jie J Chen Qiang Q Colantuoni Carlo C Ulrich William S WS Maher Brady J BJ Deep-Soboslay Amy A Cross Alan J AJ Brandon Nicholas J NJ Leek Jeffrey T JT Hyde Thomas M TM Kleinman Joel E JE Weinberger Daniel R DR
Nature neuroscience 20180726 8
Genome-wide association studies have identified 108 schizophrenia risk loci, but biological mechanisms for individual loci are largely unknown. Using developmental, genetic and illness-based RNA sequencing expression analysis in human brain, we characterized the human brain transcriptome around these loci and found enrichment for developmentally regulated genes with novel examples of shifting isoform usage across pre- and postnatal life. We found widespread expression quantitative trait loci (eQ ...[more]