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C-H 18F-fluorination of 8-methylquinolines with Ag[18F]F.

ABSTRACT: This report describes a Pd-mediated C-H radiofluorination of 8-methylquinoline derivatives with no-carrier-added Ag[18F]F. To achieve this transformation, a new method was developed for the generation of Ag[18F]F using a sep-pak cartridge. The C-H radiofluorination was then optimized and applied to a series of substituted 8-methylquinoline derivatives. Finally, this method was fully automated using a radiochemistry synthesis module.

SUBMITTER: Lee SJ

PROVIDER: S-EPMC6556205 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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C-H <sup>18</sup>F-fluorination of 8-methylquinolines with Ag[<sup>18</sup>F]F.

Lee So Jeong SJ Brooks Allen F AF Ichiishi Naoko N Makaravage Katarina J KJ Mossine Andrew V AV Sanford Melanie S MS Scott Peter J H PJH

Chemical communications (Cambridge, England) 20190301 20

This report describes a Pd-mediated C-H radiofluorination of 8-methylquinoline derivatives with no-carrier-added Ag[18F]F. To achieve this transformation, a new method was developed for the generation of Ag[18F]F using a sep-pak cartridge. The C-H radiofluorination was then optimized and applied to a series of substituted 8-methylquinoline derivatives. Finally, this method was fully automated using a radiochemistry synthesis module. ...[more]

PMID: 30778496

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