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Suzuki Cross-Coupling of [2.2]Paracyclophane Trifluoroborates with Pyridyl and Pyrimidyl Building Blocks.

ABSTRACT: We report a new Suzuki cross-coupling protocol for high yielding derivatization of [2.2]paracyclophane with pyridyl and pyrimidyl substituents. The [2.2]paracyclophane trifluoroborate salt presented herein is a bench stable, easily accessible, and convenient substitute to former cross-coupling substrates. This will be of very high interest for future paracyclophane derivatization endeavors.

SUBMITTER: Knoll DM

PROVIDER: S-EPMC6645350 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Suzuki Cross-Coupling of [2.2]Paracyclophane Trifluoroborates with Pyridyl and Pyrimidyl Building Blocks.

Knoll Daniel M DM Bräse Stefan S

ACS omega 20180927 9

We report a new Suzuki cross-coupling protocol for high yielding derivatization of [2.2]paracyclophane with pyridyl and pyrimidyl substituents. The [2.2]paracyclophane trifluoroborate salt presented herein is a bench stable, easily accessible, and convenient substitute to former cross-coupling substrates. This will be of very high interest for future paracyclophane derivatization endeavors. ...[more]

PMID: 31459290

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