Nitric oxide-releasing alginates as mucolytic agents.
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ABSTRACT:
SUBMITTER: Ahonen MJR
PROVIDER: S-EPMC7164775 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
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Nitric oxide-releasing alginates as mucolytic agents.
Ahonen Mona Jasmine R MJR Hill David B DB Schoenfisch Mark H MH
ACS biomaterials science & engineering 20190524 7
The excessive production of thick, viscous mucus in severe respiratory diseases leads to obstruction of the airways and provides a suitable environment for the colonization of pathogenic bacteria. The effect of nitric oxide (NO)-releasing alginates with varying NO release kinetics on the viscoelastic properties of human bronchial epithelial (HBE) mucus was evaluated as a function of the NO-release kinetics using parallel plate rheology. Low molecular weight (~5 kDa) alginates with high NO flux ( ...[more]
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