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Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus.

ABSTRACT: Seven known echinulin-related indolediketopiperazine alkaloids (1-7) were isolated from the Vietnamese sediment-derived fungus Aspergillus niveoglaucus. Using chiral HPLC, the enantiomers of cryptoechinuline B (1) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B (1a) exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson's disease. (-)-Cryptoechinuline B (1b) and neoechinulin C (5) protected the neuronal cells against paraquat-induced damage in a Parkinson's disease model. Neoechinulin B (4) exhibited cytoprotective activity in a rotenone-induced model, and neoechinulin (7) showed activity in the 6-OHDA-induced model.

SUBMITTER: Smetanina OF 

PROVIDER: S-EPMC6983058 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Seven known echinulin-related indolediketopiperazine alkaloids (<b>1</b>-<b>7</b>) were isolated from the Vietnamese sediment-derived fungus <i>Aspergillus niveoglaucus</i>. Using chiral HPLC, the enantiomers of cryptoechinuline B (<b>1</b>) were isolated as individual compounds for the first time. (+)-Cryptoechinuline B (<b>1a</b>) exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson's disease. (-)-Cryptoechinuline B (<b>1b</b>) and neoechi  ...[more]

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