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Azonazine, a novel dipeptide from a Hawaiian marine sediment-derived fungus, Aspergillus insulicola.

ABSTRACT: Azonazine, a unique hexacyclic dipeptide, was isolated from a Hawaiian marine sediment-derived fungus eventually identified as Aspergillus insulicola. Its absolute configuration, 2R,10R,11S,19R, was established using NMR, HRESIMS, and CD data plus insights derived from molecular models. A possible route for its biogenesis is proposed, and biological properties were explored against cancer cell lines and in an NF?B inhibition assay.

SUBMITTER: Wu QX

PROVIDER: S-EPMC2953366 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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Azonazine, a novel dipeptide from a Hawaiian marine sediment-derived fungus, Aspergillus insulicola.

Wu Quan-Xiang QX Crews Mitchell S MS Draskovic Marija M Sohn Johann J Johnson Tyler A TA Tenney Karen K Valeriote Frederick A FA Yao Xiao-Jun XJ Bjeldanes Leonard F LF Crews Phillip P

Organic letters 20101001 20

Azonazine, a unique hexacyclic dipeptide, was isolated from a Hawaiian marine sediment-derived fungus eventually identified as Aspergillus insulicola. Its absolute configuration, 2R,10R,11S,19R, was established using NMR, HRESIMS, and CD data plus insights derived from molecular models. A possible route for its biogenesis is proposed, and biological properties were explored against cancer cell lines and in an NFκB inhibition assay. ...[more]

PMID: 20866076

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