Ontology highlight
ABSTRACT:
SUBMITTER: DiFiore JV
PROVIDER: S-EPMC7334899 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
DiFiore Julia V JV Ptacek Travis S TS Wang Yi Y Li Bing B Simon Jeremy M JM Strahl Brian D BD
Cell reports 20200601 10
Set2 co-transcriptionally methylates lysine 36 of histone H3 (H3K36), producing mono-, di-, and trimethylation (H3K36me1/2/3). These modifications recruit or repel chromatin effector proteins important for transcriptional fidelity, mRNA splicing, and DNA repair. However, it was not known whether the different methylation states of H3K36 have distinct biological functions. Here, we use engineered forms of Set2 that produce different lysine methylation states to identify unique and shared function ...[more]