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A Coumarin-Based Fluorescent Probe for Ratiometric Detection of Cu2+ and Its Application in Bioimaging.


ABSTRACT: The fluorescent probe L, based on naphthalimide-modified coumarin, was designed, synthesized, and characterized, which could recognize Cu2+ from other cations selectively and sensitively in HEPES buffer (10 mM, Ph = 7. 4)/CH3CN (1:4, V/V). When the probe L interacted with Cu2+, the color and the fluorescent intensity changed obviously and it provided the naked-eye detection for Cu2+. The recognition mode between them was achieved by Job's plot, IR, MS, SEM, and 1HNMR. In addition, test strips made from L could still interact with Cu2+ in tap water effectively. The limit of detection (LOD) of L was 3.5 × 10-6 M. Additionally, the density functional theory (DFT) calculation method was used to analyze the action mechanism of L toward Cu2+. Importantly, the fluorescent probe L could demonstrate favorable selectivity toward Cu2+ in Caenorhabditis elegans. Thus, L was considered to have some potential for application in bioimaging.

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7573568 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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A Coumarin-Based Fluorescent Probe for Ratiometric Detection of Cu<sup>2+</sup> and Its Application in Bioimaging.

Zhang Jie J   Chen Meng-Yu MY   Bai Cui-Bing CB   Qiao Rui R   Wei Biao B   Zhang Lin L   Li Rui-Qian RQ   Qu Chang-Qing CQ  

Frontiers in chemistry 20201002


The fluorescent probe <b>L</b>, based on naphthalimide-modified coumarin, was designed, synthesized, and characterized, which could recognize Cu<sup>2+</sup> from other cations selectively and sensitively in HEPES buffer (10 mM, Ph = 7. 4)/CH<sub>3</sub>CN (1:4, V/V). When the probe <b>L</b> interacted with Cu<sup>2+</sup>, the color and the fluorescent intensity changed obviously and it provided the naked-eye detection for Cu<sup>2+</sup>. The recognition mode between them was achieved by Job's  ...[more]

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