Ontology highlight
ABSTRACT:
SUBMITTER: Nuno-Cabanes C
PROVIDER: S-EPMC7594455 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Nuño-Cabanes Carme C García-Molinero Varinia V Martín-Expósito Manuel M Gas María-Eugenia ME Oliete-Calvo Paula P García-Oliver Encar E de la Iglesia-Vayá María M Rodríguez-Navarro Susana S
Epigenetics & chromatin 20201028 1
<h4>Background</h4>Histone H2B deubiquitination is performed by numerous deubiquitinases in eukaryotic cells including Ubp8, the catalytic subunit of the tetrameric deubiquitination module (DUBm: Ubp8; Sus1; Sgf11; Sgf73) of the Spt-Ada-Gcn5 acetyltransferase (SAGA). Ubp8 is linked to the rest of SAGA through Sgf73 and is activated by the adaptors Sus1 and Sgf11. It is unknown if DUBm/Ubp8 might also work in a SAGA-independent manner.<h4>Results</h4>Here we report that a tetrameric DUBm is assem ...[more]