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ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway.

ABSTRACT: Recently, COVID-19 caused by the novel coronavirus SARS-CoV-2 has brought great challenges to the world. More and more studies have shown that patients with severe COVID-19 may suffer from cytokine storm syndrome; however, there are few studies on its pathogenesis. Here we demonstrated that SARS-CoV-2 coding protein open reading frame 8 (ORF8) acted as a contributing factor to cytokine storm during COVID-19 infection. ORF8 could activate IL-17 signaling pathway and promote the expression of pro-inflammatory factors. Moreover, we demonstrated that treatment of IL17RA antibody protected mice from ORF8-induced inflammation. Our findings are helpful to understand the pathogenesis of cytokine storm caused by SARS-CoV-2 and provide a potential target for the development of COVID-19 therapeutic drugs.

SUBMITTER: Lin X

PROVIDER: S-EPMC7942160 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection.

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2022-08-12 | PXD032035 | Pride

Transplacental SARS-CoV-2 protein ORF8 binds to complement C1q to trigger fetal inflammation

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