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Copper-catalyzed monoselective C-H amination of ferrocenes with alkylamines.

ABSTRACT: A copper-catalyzed mono-selective C-H amination of ferrocenes assisted by 8-aminoquinoline is presented here. A range of amines, including bioactive molecules, were successfully installed to the ortho-position of ferrocene amides with high efficiency under mild conditions. A range of functionalized ferrocenes were compatible to give the aminated products in moderate to good yields. The gram-scale reaction was smoothly conducted and the directing group could be removed easily under basic conditions.

SUBMITTER: Jia ZS

PROVIDER: S-EPMC8491713 | biostudies-literature |

REPOSITORIES: biostudies-literature

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