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Tandem Transesterification-Esterification Reactions Using a Hydrophilic Sulfonated Silica Catalyst for the Synthesis of Wintergreen Oil from Acetylsalicylic Acid Promoted by Microwave Irradiation.

ABSTRACT: SiO₂-SO₃H, with a surface area of 115 m²/g and pore volume of 0.38 cm³g^-1, and 1.32 mmol H⁺/g was used as a 20% w/w catalyst for the preparation of methyl salicylate (wintergreen oil or MS) from acetylsalicylic acid (ASA). A 94% conversion was achieved in a microwave reactor over 40 min at 120 °C in MeOH. The resulting crude product was purified by flash chromatography. The catalyst could be reused three times.

SUBMITTER: Barbosa SL

PROVIDER: S-EPMC9330306 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Tandem Transesterification-Esterification Reactions Using a Hydrophilic Sulfonated Silica Catalyst for the Synthesis of Wintergreen Oil from Acetylsalicylic Acid Promoted by Microwave Irradiation.

Barbosa Sandro L SL Nelson David Lee DL Freitas Milton de S MS Dos Santos Wallans Torres Pio WTP Klein Stanlei I SI Clososki Giuliano C GC Caires Franco J FJ Wentz Alexandre P AP

Molecules (Basel, Switzerland) 20220726 15

SiO2-SO3H, with a surface area of 115 m2/g and pore volume of 0.38 cm3g-1, and 1.32 mmol H+/g was used as a 20% w/w catalyst for the preparation of methyl salicylate (wintergreen oil or MS) from acetylsalicylic acid (ASA). A 94% conversion was achieved in a microwave reactor over 40 min at 120 °C in MeOH. The resulting crude product was purified by flash chromatography. The catalyst could be reused three times. ...[more]

PMID: 35897943

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