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CryoEM structure of human LRRC8D


ABSTRACT:

SUBMITTER: Osamu Nureki 

PROVIDER: EMPIAR-10383 | biostudies-other |

REPOSITORIES: biostudies-other

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Members of the leucine-rich repeat-containing 8 (LRRC8) protein family, composed of the five LRRC8A-E isoforms, are pore-forming components of the volume-regulated anion channel (VRAC). LRRC8A and at least one of the other LRRC8 isoforms assemble into heteromers to generate VRAC transport activities. Despite the availability of the LRRC8A structures, the structural basis of how LRRC8 isoforms other than LRRC8A contribute to the functional diversity of VRAC has remained elusive. Here, we present  ...[more]

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