Ontology highlight
ABSTRACT:
SUBMITTER: Osamu Nureki
PROVIDER: EMPIAR-10383 | biostudies-other |
REPOSITORIES: biostudies-other
Nakamura Ryoki R Numata Tomohiro T Kasuya Go G Yokoyama Takeshi T Nishizawa Tomohiro T Kusakizako Tsukasa T Kato Takafumi T Hagino Tatsuya T Dohmae Naoshi N Inoue Masato M Watanabe Kengo K Ichijo Hidenori H Kikkawa Masahide M Shirouzu Mikako M Jentsch Thomas J TJ Ishitani Ryuichiro R Okada Yasunobu Y Nureki Osamu O
Communications biology 20200515 1
Members of the leucine-rich repeat-containing 8 (LRRC8) protein family, composed of the five LRRC8A-E isoforms, are pore-forming components of the volume-regulated anion channel (VRAC). LRRC8A and at least one of the other LRRC8 isoforms assemble into heteromers to generate VRAC transport activities. Despite the availability of the LRRC8A structures, the structural basis of how LRRC8 isoforms other than LRRC8A contribute to the functional diversity of VRAC has remained elusive. Here, we present ...[more]