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Cryo-electron tomography of FIB-milled Caulobacter crescentus expressing WT PopZ


ABSTRACT:

SUBMITTER: Vinson Lam 

PROVIDER: EMPIAR-10688 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems.

Lasker Keren K   Boeynaems Steven S   Lam Vinson V   Scholl Daniel D   Stainton Emma E   Briner Adam A   Jacquemyn Maarten M   Daelemans Dirk D   Deniz Ashok A   Villa Elizabeth E   Holehouse Alex S AS   Gitler Aaron D AD   Shapiro Lucy L  

Nature communications 20220926 1


Intracellular phase separation is emerging as a universal principle for organizing biochemical reactions in time and space. It remains incompletely resolved how biological function is encoded in these assemblies and whether this depends on their material state. The conserved intrinsically disordered protein PopZ forms condensates at the poles of the bacterium Caulobacter crescentus, which in turn orchestrate cell-cycle regulating signaling cascades. Here we show that the material properties of t  ...[more]

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