Dataset Information
Single-particle cryo-EM dataset of the complex between ALC1 and a PARylated nucleosome
Ontology highlight
ABSTRACT:
SUBMITTER: Guillaume Gaullier
PROVIDER: EMPIAR-10739 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome.
eLife 20210906
The chromatin remodeler ALC1 is recruited to and activated by DNA damage-induced poly(ADP-ribose) (PAR) chains deposited by PARP1/PARP2/HPF1 upon detection of DNA lesions. ALC1 has emerged as a candidate drug target for cancer therapy as its loss confers synthetic lethality in homologous recombination-deficient cells. However, structure-based drug design and molecular analysis of ALC1 have been hindered by the requirement for PARylation and the highly heterogeneous nature of this post-translatio ...[more]