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Single-particle cryo-EM dataset of an asymmetric nucleosome (10-N-0)

ABSTRACT:

SUBMITTER: Guillaume Gaullier

PROVIDER: EMPIAR-11618 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome.

Bacic Luka L Gaullier Guillaume G Sabantsev Anton A Lehmann Laura C LC Brackmann Klaus K Dimakou Despoina D Halic Mario M Hewitt Graeme G Boulton Simon J SJ Deindl Sebastian S

eLife 20210906

The chromatin remodeler ALC1 is recruited to and activated by DNA damage-induced poly(ADP-ribose) (PAR) chains deposited by PARP1/PARP2/HPF1 upon detection of DNA lesions. ALC1 has emerged as a candidate drug target for cancer therapy as its loss confers synthetic lethality in homologous recombination-deficient cells. However, structure-based drug design and molecular analysis of ALC1 have been hindered by the requirement for PARylation and the highly heterogeneous nature of this post-translatio ...[more]

PMID: 34486521

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