High resolution 3D imaging of liver subcellular architecture and its link to metabolic function
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ABSTRACT:
SUBMITTER: Gunes Parlakgul
PROVIDER: EMPIAR-10791 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Regulation of liver subcellular architecture controls metabolic homeostasis.
Parlakgül Güneş G Arruda Ana Paula AP Pang Song S Cagampan Erika E Min Nina N Güney Ekin E Lee Grace Yankun GY Inouye Karen K Hess Harald F HF Xu C Shan CS Hotamışlıgil Gökhan S GS
Nature 20220309 7902
Cells display complex intracellular organization by compartmentalization of metabolic processes into organelles, yet the resolution of these structures in the native tissue context and their functional consequences are not well understood. Here we resolved the three-dimensional structural organization of organelles in large (more than 2.8 × 10<sup>5</sup> µm<sup>3</sup>) volumes of intact liver tissue (15 partial or full hepatocytes per condition) at high resolution (8 nm isotropic pixel size) u ...[more]
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