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Cryo-electron microscopy reconstruction of ATP-bound ABCA4 (E1087Q/E2096Q)

ABSTRACT:

SUBMITTER: Jue Chen

PROVIDER: EMPIAR-10811 | biostudies-other |

REPOSITORIES: biostudies-other

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Molecular structures of the eukaryotic retinal importer ABCA4.

Liu Fangyu F Lee James J Chen Jue J

eLife 20210219

The ATP-binding cassette (ABC) transporter family contains thousands of members with diverse functions. Movement of the substrate, powered by ATP hydrolysis, can be outward (export) or inward (import). ABCA4 is a eukaryotic importer transporting retinal to the cytosol to enter the visual cycle. It also removes toxic retinoids from the disc lumen. Mutations in ABCA4 cause impaired vision or blindness. Despite decades of clinical, biochemical, and animal model studies, the molecular mechanism of A ...[more]

PMID: 33605212

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