Dataset Information
Cryo-electron microscopy reconstruction of PCAT1 bound to its CtA peptide substrate
Ontology highlight
ABSTRACT:
SUBMITTER: Jue Chen
PROVIDER: EMPIAR-10818 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural basis of substrate recognition by a polypeptide processing and secretion transporter.
eLife 20200114
The peptidase-containing ATP-binding cassette transporters (PCATs) are unique members of the ABC transporter family that proteolytically process and export peptides and proteins. Each PCAT contains two peptidase domains that cleave off the secretion signal, two transmembrane domains forming a translocation pathway, and two nucleotide-binding domains that hydrolyze ATP. Previously the crystal structures of a PCAT from <i>Clostridium thermocellum</i> (PCAT1) were determined in the absence and pres ...[more]