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Cryo-electron microscopy reconstruction of human TAP Transporter bound to Herpes Simplex Virus 1 Inhibitor ICP47

ABSTRACT:

SUBMITTER: Jue Chen

PROVIDER: EMPIAR-10816 | biostudies-other |

REPOSITORIES: biostudies-other

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Structure of the transporter associated with antigen processing trapped by herpes simplex virus.

Oldham Michael L ML Grigorieff Nikolaus N Chen Jue J

eLife 20161209

The transporter associated with antigen processing (TAP) is an ATP-binding cassette (ABC) transporter essential to cellular immunity against viral infection. Some persistent viruses have evolved strategies to inhibit TAP so that they may go undetected by the immune system. The herpes simplex virus for example evades immune surveillance by blocking peptide transport with a small viral protein ICP47. In this study, we determined the structure of human TAP bound to ICP47 by electron cryo-microscopy ...[more]

PMID: 27935481

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