Dataset Information
CryoEM structure of Go-coupled 5-HT5AR in complex with Methylergometrine
Ontology highlight
ABSTRACT:
SUBMITTER: Jonathan Firoze Fay
PROVIDER: EMPIAR-11039 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Inactive and active state structures template selective tools for the human 5-HT<sub>5A</sub> receptor.
Nature structural & molecular biology 20220714 7
Serotonin receptors are important targets for established therapeutics and drug development as they are expressed throughout the human body and play key roles in cell signaling. There are 12 serotonergic G protein-coupled receptor members encoded in the human genome, of which the 5-hydroxytryptamine (5-HT)<sub>5A</sub> receptor (5-HT<sub>5A</sub>R) is the least understood and lacks selective tool compounds. Here, we report four high-resolution (2.73-2.80 Å) structures of human 5-HT<sub>5A</sub>R ...[more]