Dataset Information
Cryo-electron tomogram of mitochondria in cryo-FIB milled mouse embryonic fibroblasts with OPA1 deletion
Ontology highlight
ABSTRACT:
SUBMITTER: Luke Chao
PROVIDER: EMPIAR-11817 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
In situ architecture of Opa1-dependent mitochondrial cristae remodeling.
The EMBO journal 20240115 3
Cristae membrane state plays a central role in regulating mitochondrial function and cellular metabolism. The protein Optic atrophy 1 (Opa1) is an important crista remodeler that exists as two forms in the mitochondrion, a membrane-anchored long form (l-Opa1) and a processed short form (s-Opa1). The mechanisms for how Opa1 influences cristae shape have remained unclear due to lack of native three-dimensional views of cristae. We perform in situ cryo-electron tomography of cryo-focused ion beam m ...[more]